2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-125053
    Batifiban 710312-77-9 98%
    Batifiban, a cyclic peptide, is a platelet glycoprotein GPⅡb/Ⅲa antagonist, and inhibits platelet aggregation. Batifiban blocks circulating vitronectin binding to integrin ανβ3, Batifiban can be used for research of acute coronary syndromes.
    Batifiban
  • HY-125061
    Hydroxythiohomosildenafil 479073-82-0 98%
    Hydroxythiohomosildenafil is a Sildenafil (HY-15025) class compound that can be used to study erectile dysfunction.
    Hydroxythiohomosildenafil
  • HY-125093
    SL-870495 120560-67-0 98%
    SL-870495 is a calcium antagonist targeting L-type calcium channels. SL-870495 is promising for research of cardiovascular diseases such as hypertension and angina pectoris.
    SL-870495
  • HY-125094
    L-162782 169281-92-9 98%
    L-162782 is a high affinity AT1 receptor ligand for rat and human wild-type AT1 with IC50 values of 28.5 and 24.6 nM, respectively. L-162782 acts as a partial agonist (EC50 ≈ 30 nM) and insurmountable antagonist (IC50 = 6.5 μM) on wild-type rat AT1 receptors in COS-7 cells. L-162782 reduces Angiotensin II (HY-13948)-induced phosphatidylinositol turnover. L-162782 can be used for hypertension research.
    L-162782
  • HY-125123
    Euchrestaflavanone A 80510-05-0 98%
    Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis.
    Euchrestaflavanone A
  • HY-125313
    PSB-1737 139896-80-3 98%
    PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 270 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 μM). PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia.
    PSB-1737
  • HY-125324
    Squalestatin 3 142505-92-8 98%
    Squalestatin 3 is a secondary metabolite, which can be isolated from Phoma. Squalestatin 3 is an inhibitor for squalene synthase with an IC50 of 6 nM.
    Squalestatin 3
  • HY-12533B
    Disopyramide hydrochloride 54687-36-4 98%
    Disopyramide hydrochloride is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide hydrochloride blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide hydrochloride inhibits HERG encoded potassium channels. Disopyramide hydrochloride also exhibits complex protein binding, and has a potent negative inotropic action.
    Disopyramide hydrochloride
  • HY-125341
    Microginin 527 1135249-50-1 98%
    Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds.
    Microginin 527
  • HY-125373
    L-767685 183745-58-6 98%
    L-767685, the ethyl ester prodrug of L-767679 (HY-116925), is a non-peptide glycoprotein IIb/IIIa receptor (GPIIb-IIIa receptor) antagonist. L-767679 has a potent anti-platelet aggregation effect. L-767685 can be used for research on antithrombosis.
    L-767685
  • HY-125386
    SQ 32056 139113-49-8 98%
    SQ 32056 is a cathepsin E inhibitor. SQ 32056 can block the pressor response to endothelin.
    SQ 32056
  • HY-125404
    DAPK-IN-1 313971-05-0 98%
    DAPK-IN-1 is a DAPK1 and DAPK3 inhibitor. DAPK-IN-1 is applicable to research related to cerebral infarction, myocardial infarction and renal failure.
    DAPK-IN-1
  • HY-125475
    Rivipansel 927881-99-0 98%
    Rivipansel is a small-molecule glycomimetic pan-selectin antagonist with inhibitory activity against E-selectin and P-selectin. Rivipansel binds tightly to the lectin domain of E-selectin, and selectively blocks the recognition of CD62L by E-selectin without affecting the binding of PSGL-1 to E-selectin. Rivipansel functionally inhibits the adhesion of hematopoietic cells to endothelial cells, and is applicable to research related to sickle cell disease.
    Rivipansel
  • HY-125528
    Ro 09-1679 141426-89-3 98%
    Ro 09-1679 is a thrombin inhibitor, with an IC50 of 33.6 μM. Ro 09-1679 inhibits the enzyme activities, with IC50 values of 3.3, 0.04 and 0.0346 μM for factor Xa, trypsin and papain, respectively.
    Ro 09-1679
  • HY-125554
    KDdiA-PC 439904-34-4 98%
    KDdiA-PC is one of the most potent CD36 ligands in oxidized LDL (oxLDL).
    KDdiA-PC
  • HY-125601
    Iosimenol 181872-90-2 98%
    Iosimenol is a low-viscosity iso-osmolar iodinated contrast medium. Iosimenol can be used in research related to angiography.
    Iosimenol
  • HY-125626
    8-iso-15-keto Prostaglandin F2α 191919-01-4 98%
    8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto Prostaglandin F2α mediates a weak relaxation of rats aorta rings at high concentration.
    8-iso-15-keto Prostaglandin F2α
  • HY-125705
    Herquline A 71812-08-3 98%
    Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus.
    Herquline A
  • HY-126081
    (8-epi)-BW 245C 65705-83-1 98%
    (8-epi)-BW 245C is the C-8 diastereomer of BW 245C (HY-101987). BW 245 C is a high affinity and selective PGD2 receptor agonist.
    (8-epi)-BW 245C
  • HY-126084
    Carbaprostacyclin methyl ester 69552-55-2 98%
    Carbaprostacyclin methyl ester is a methylated derivative of Carbacyclin (HY-112322).
    Carbaprostacyclin methyl ester
Cat. No. Product Name / Synonyms Application Reactivity